This study provides evidence that Stenotrophomonas maltophilia encodes an enzyme that is capable of degrading tetracycline antibiotics, even if such a mechanism is not essential for its resistance to them @CVUTPraha @IUCr #Tetracycline #AntibioticResistance https://doi.org/10.1107/S2053230X23005381

More concerns about #GE mosquitoes -- especially since they can breed when exposed to #tetracycline

Behind an academic paywall:

Science snipes at #Oxitec transgenic-mosquito trial

by Nidhi Subbaraman

Nature Biotechnology volume 29, pages 9–10 (2011)

"#Oxitec's plans for transgenic #mosquito trials have not been without controversy in the past. They have been criticized by environmental groups, such as Ottawa-based #ETCGroup and #EcoNexus of Oxford, concerned about the risks of releasing an entirely new strain of organism into the environment".

#GM #GeneticEngineering #mosquitoes

https://www.nature.com/articles/nbt0111-9a/

So, yeah, concerns about #Oxitec #GE #GM #mosquitoes were brushed off as "conspiracy theories" (probably twisted by Q-Anon types), but it turns out that those concerns were real. To summarize, GE mosquitoes, allegedly bred to be sterile, become not-so-sterile when exposed to #Tetracycline -- a common antibiotic used in cattle, companion animals, and humans!

Following Review of Available Data and Public Comments, EPA Expands and Extends Testing of Genetically Engineered Mosquitoes to Reduce Mosquito Populations
For Release: March 7, 2022

"To ensure that no OX5034 female mosquito offspring survive, EPA has taken the precaution of restricting release of OX5034 mosquitos within 500 meters of potential sources of tetracyclines, as there is a remote chance that environmental sources of tetracycline could have enough tetracycline present to act as a counter agent to the OX5034 female mosquito-lethal trait. Releases must not occur within 500 meters from the outer perimeter of 1) wastewater treatment facilities; 2) commercial citrus, apple, pear, nectarine, and peach crops; and 3) commercial cattle, poultry, and pig livestock facilities. The 500-meter distance creates a conservative buffer zone between OX5034 release points and potential environmental tetracycline sources."
"Oxitec must monitor for OX5034 female mosquitoes within 100 meters of those potential environmental tetracycline sources."
https://www.epa.gov/pesticides/following-review-available-data-and-public-comments-epa-expands-and-extends-testing

Based on a nanosystem, the core of which is #polyoxometalate (containing #molybdenum and iron). A broad-spectrum #antibiotic, #tetracycline, is attached to the surface of the polyoxometalate.
#Chemistry #Nanotechnology #Pharmaceutical #sflorg
https://www.sflorg.com/2023/01/nt01182301.html