#IDMastodon MedSky🧪Veno-venous extracorporeal membrane oxygenation (ECMO) can be lifesaving in patients with severe #COVID19
@deepaarachchil1 et al find major bleeding and arterial and circuit #thrombosis ▶️📈 mortality.
@jthjournal
https://www.jthjournal.org/article/S1538-7836(23)00520-2/fulltext

''#Necropsy consistently revealed pulmonary #congestion and #oedema, and cerebrocortical malacia with #haemorrhage was also seen in the cat that survived for 10 days. On #histology, all cats had necrotizing #encephalitis and interstitial #pneumonia with pulmonary congestion, oedema, #vasculitis and vascular #thrombosis. One cat also had microscopic multifocal necrosis in the #liver, #pancreas and an adrenal gland.''

With respect to diffuse alveolar damage in #SARS-CoV2
formation of fibrin thrombi has been observed anecdotally but not studied systematically
Clinically, many patients have elevated D-dimer levels,
cutaneous changes in their extremities suggesting thrombotic microangiopathy
Diffuse intravascular coagulation and large-vessel thrombosis have been linked to multisystem organ failure

Pulmonary #Vascular #Endothelialitis, #Thrombosis, and Angiogenesis in #COVID19
- PMC

👇
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412750/

Supermarket trolley sensors could help to identify risk of stroke, say scientists

'Study with 2,155 participants at Sainsbury’s stores leads to atrial fibrillation diagnosis for 39 people unaware they had condition'

An Apple Watch can tell you quicker, but the more people reached the better.

#science #medicine #health #thrombosis #stroke #AtrialFibrillation

https://www.theguardian.com/society/2023/jun/23/supermarket-trolley-sensors-ecg-atrial-fibrillation-stroke-trial-research

https://www.science.org/doi/10.1126/science.abo5044 “By examining blood from humans experiencing chronic #immobilization, healthy volunteers on extendedBedRest, and free-ranging #BrownBears during their periods of activity and #hibernation, Thienel et al. identified specific #proteins that are down-regulated during periods of prolonged immobility and protect from #thrombosis”

The paradox of #thrombosis: Determining how #hibernating bears and paraplegics avoid blood #clots.

#proteomics #HSP47

https://phys.org/news/2023-04-paradox-thrombosis-hibernating-paraplegics-blood.html

High-dose prophylactic #anticoagulation is (was?) affective to reduce the occurence of #thrombosis without impacting outcomes in #Covid hypoxemic failure

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2802821

#JAMAInternalMedicine #FOAMcc #CriticalCare

A trial on 4F-PPC impact on #transfusion in #trauma. Included population seems appropriate, no effect of transfusion, more #thrombosis

https://jamanetwork.com/journals/jama/fullarticle/2802855

#JAMA #Isicem #CriticalCare

So, there is a clot at the catheter insertion point. What the point? It’s not a bug, it’s a feature!

I mean, if there's a hole in a big vessel, you want your blood to form a clot so you don't die from bleeding for exemple

https://pubmed.ncbi.nlm.nih.gov/36892598/

#ICM #CriticalCare #Thrombosis

The artificial #sweetener #erythritol increases risk for major adverse cardiovascular events, and is linked to heightened platelet reactivity and #thrombosis potential in humans. #CVD #stroke #myocardialinfarction #death #nutrition https://www.nature.com/articles/s41591-023-02223-9

Erythritol wordt in de markt gezet als een veilige zoetstof, maar blijkt toch risico's met zich mee te brengen voor hart en bloedvaten.

Zero-Cal Sweetener Erythritol Disappoints on Cardiovascular Safety
https://www.medpagetoday.com/cardiology/prevention/103281?xid=nl_mpt_morningbreak2023-02-28&eun=g1662303d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=MorningBreak_022823&utm_term=NL_Gen_Int_Daily_News_Update_active

#zoetstof #sweetener #diet #weightloss #afvallen #thrombosis

#IDMastodon @atvbahajournals Caught at the Scene of the Crime: #platelets and #Neutrophils Are Conspirators in #thrombosis & #COViD19
📌 https://www.ahajournals.org/doi/10.1161/ATVBAHA.121.317187#.Y_jvDV6ZrdE.twitter
📌 https://www.ahajournals.org/journal/atvb

#IDMastodon #hemostasis #Immnunology #Clinicalreviews In patients with #COVID19, #antiphospholipid #antibodies may help identify an increased risk of #thrombosis and other adverse outcomes.
https://www.sciencedirect.com/science/article/pii/S2475037923000067#fig1
@RPTHjournal
https://www.sciencedirect.com/journal/research-and-practice-in-thrombosis-and-haemostasis/vol/7/issue/1

#EndothelialCell #Sirt6 deficiency->
⏫#TissueFactor/F3+vascular inflammation genes Cox2, VCAM1, TNFα, MCP1
Accelerated Carotid arterial #Thrombosis (Rose bengal)

A role in atherosclerotic plaque stability?😃

Dr. Christian Matter lab JMCC 2022
https://www.jmcc-online.com/article/S0022-2828(22)00565-X/fulltext

Ultrasound Tornadoes Destroy Brain Blood Clots:
North Carolina State mechanical engineers report that vortex ultrasound dissolves blood clots in critical brain blood vessels faster. #ultrasound #vortex #brain #thrombosis #stroke #hemorrhage

https://youtu.be/YV8r-_z2OXk

#IDMastodon Prevention of 🏥 associated #thrombosis in #PalliativeCare remains controversial .Documented risk assessment where appropriate pharmacological prophylaxis of inpatients with advanced cancer. Right needle, right patient, right time are important.
📌 https://www.sciencedirect.com/science/article/abs/pii/S0049384823000282?dgcid=raven_sd_aip_email
📌 https://www.sciencedirect.com/science/article/pii/S1521692622000032
📌 https://www.sciencedirect.com/science/article/pii/S1521692622000044

What we can learn from blood cell chit-chat – Listen to Prof. Oliver Hayden in this TEDxTUM talk: http://go.tum.de/846903

#thrombosis #bloodcells

Yes - this is something we need!

"Which trial do we need? Infectious and non-infectious complications of peripherally-inserted central venous catheters and midline catheters" - Clinical Microbiology and Infection

#IDmastodon #MedMastodon #catheter #academia #medicine #infection #thrombosis

https://www.sciencedirect.com/science/article/pii/S1198743X23000368#bib8

RT @Salles_Crawley@twitter.com

Check out our latest review on #platelets and #neutrophils in #thrombosis !
http://doi.org/10.3390/ijms24021266
@StGeorgesUni@twitter.com @ImperialImmuno@twitter.com

🐦🔗: https://twitter.com/Salles_Crawley/status/1616180565262340096

RT @JTHjournal@twitter.com

The practice of anticoagulation in ECMO is variable & challenging; high risk of both #bleeding & #thrombosis
@isth@twitter.com SCC guidance paper provides guidance on the clinical aspects of ECMO anticoagulation management! @connors_md@twitter.com @JerroldLevy@twitter.com
https://lnkd.in/gdN8Zrzi

🐦🔗: https://twitter.com/JTHjournal/status/1615348223379390464