First Total Syntheses of Hyperireflexolides A and B: Bioinspired pathway involves dearomatization and fragmentation of an acylphloroglucinol

https://bit.ly/44uEA2n

#chemistry #chemistryviews #chemviews #chemiverse #totalsynthesis #organicchemistry #research

Synthesis of highly complex terpenoids reported by Shuanhu Gao and co-workers from the East China Normal #University (#Shanghai #China). Cephinoid P and other related terpenoids were accessible by Nicholas/Hosomi-Sakurai cascade reaction and Pauson-Khand reaction. Published in #JACS

#chemistry #TotalSynthesis

https://pubs.acs.org/doi/10.1021/jacs.3c05455

Total Synthesis of Mindapyrroles A and B: Investigation of the antibacterial activity and the mechanism of action of two natural products

https://bit.ly/46TUOo1

#chemistry #chemistryviews #chemviews # chemiverse #Research #totalsynthesis #organicchemistry #chemcon

First Total Synthesis of Thiamyxins A–C and E: Potent class of RNA-virus-inhibiting (cyclo)depsipeptides

https://bit.ly/45IbZs0

#chemistry #chemistryviews #chemviews #research #chemiverse #chemcon #totalsynthesis #virus

Total Synthesis of Chaetoglobin A: Dimeric alkaloid from a fungus has a chiral axis connecting two azaphilone systems

https://bit.ly/45sts7F

#chemistry #chemistryviews #chemviews #scicon #chemivere #research #totalsynthesis #organicsynthesis #lab #science

The total synthesis of lucidumone, a ganoderma meroterpenoid, has been achieved by a team led by Hisanaka Ito from the #Tokyo University of Pharmacy and Life Sciences in #Japan and published in #AngewandteChemie. The synthesis involved a 10-step sequence, which included a one-pot preparation of the tetracyclic core skeleton via Claisen rearrangement and intramolecular aldol reaction.

#totalsynthesis #chemistry

https://onlinelibrary.wiley.com/doi/10.1002/anie.202304132

The beauty of spirocyclic compounds: Total synthesis of illisimonin A by Markus Kalesse and co-workers from the University Hannover published recently in #JACS

Nazarov/ene cyclization lead to key intermediate for the #synthesis of this terpenoid.

#totalsynthesis #chemistry #science #research

https://pubs.acs.org/doi/10.1021/jacs.3c01262

Stephadiamine is a popular synthetic challenge which resulted in many total syntheses before. Now, Jieping Zhu (EPFL, Lausanne) and co-workers were able to report in #JACS a new route to the #alkaloid with a hasubanan core structure featuring a diastereoselective intramolecular dipolar cycloaddition.

https://doi.org/10.1021/jacs.3c00884

#chemistry #totalsynthesis

Total Syntheses of Kopsaporine, Kopsinol and Kopsiloscine A by Hongbin Zhang and co-workers from Yunnan University (#China) published in #AngewandteChemie

The syntheses of these complex alkaloids were achieved by a cascade cyclization towards the key intermediate.

https://doi.org/10.1002/anie.202218935

#chemistry #totalsynthesis @chemistry

Although the first total synthesis of taxol was accomplished nearly 30 years ago, its complex structure still motivates researchers to invent new synthetic routes. Now, Masayuki Inoue and co-workers (University of #Tokyo #Japan) published a radical-based approach to the #polyketide in the journal #AngewandteChemie

https://onlinelibrary.wiley.com/doi/10.1002/anie.202219114

@chemistry #chemistry #totalsynthesis #orgchem

Synthesis of prorocentin by Alois Fürstner and co-workers from MPI Mülheim a.d. Ruhr @maxplanckgesellschaft published in #JACS is a showcase of why total synthesis is still needed: Determination of the absolute configuration and structural revision was only possible after extensive synthetic efforts.

https://pubs.acs.org/doi/10.1021/jacs.2c12529

#chemistry #totalsynthesis @chemistry

Total Synthesis of Aculenes B and D: Natural product that could inhibit quorum sensing in bacteria

https://bit.ly/3ZswK88

#chemistry #chemviews #chemistryviews #totalsynthesis

Synthesis of rakicidin C reported by Varinder Aggarwal and colleagues (University of #Bristol, #UK) in the journal #OrganicLetters. Using their iterative assembly method and various coupling strategies yielding a highly convergent synthetic route.

#totalsynthesis #chemistry @chemistry #orgchem

https://pubs.acs.org/doi/10.1021/acs.orglett.2c03716

Total Synthesis of a Bacterial Pentasaccharide O‐Glycan: Carbohydrates on the surface of bacteria can be important for their fitness as pathogens

bit.ly/3i82FKl

#chemistry #chemistryviews #chemviews #chemiverse #research #totalsynthesis #organicchemistry #carbohydrates

Total synthesis of Alterbrassicene C:

John L Wood (Baylor University, #US) et al reported the first total synthesis of the terpenoid in #JACS (10.1021/jacs.2c12275). I feautered this #synthesis because I like these kinds of oxa-Michael cascade reactions. Since many terpenoid syntheses these days often involve CH activation strategies, it's refreshing to see other approaches in action.

Read more: https://www.organicchemistry.eu/books/total-syntheses-of-natural-products/page/total-synthesis-of-alterbrassicicene-c-j-l-wood-2022

@chemistry #chemistry #totalsynthesis #terpene

@chemistry

also featured now on my page for anyone who is interested in #totalsynthesis in general

https://www.organicchemistry.eu/books/total-syntheses-of-natural-products/page/total-synthesis-of-gibberellin-ga18-methyl-ester-m-dai-2022

Total synthesis of (−)-GA18 Methyl Ester reported by Mingji Dai from Emory University (Atlanta, #US ) published recently in #JACS featuring a skeletal rearrangement

https://pubs.acs.org/doi/10.1021/jacs.2c12470

#chemistry #totalsynthesis #organicchemistry @chemistry

I had some time to highlight the total synthesis of salimbromide from H. Lu (Westlake University, China) published two months ago in #JACS . Main selling point is the extrem short synthetic route (only 8 steps), half of the steps used before.

#chemistry #totalsynthesis @chemistry

https://www.organicchemistry.eu/books/total-syntheses-of-natural-products/page/total-synthesis-of-salimabromide-hai-hua-lu-2022

Nowadays you mainly see terpenes in total synthesis projects. Here is something else:

Total synthesis of bacterial nucleosides A201A,D and E by Xiaolei Wang from Lanzhou University (China). Published in Angewandte #Chemie featuring this interesting antibiotic.

https://onlinelibrary.wiley.com/doi/10.1002/anie.202213810

#chemistry #totalsynthesis @chemistry

Interesting #Monday read: Total synthesis of Luminamicin by Tomoyasu Hirose and Toshiaki Sunazuka and co workers (Kitasato University, Tokyo) published in #JACS

Extremly challenging synthetic route, in the end using common intermediate from degredation route and synthesis route to finish the natural product.

#chemistry #totalsynthesis @chemistry

https://pubs.acs.org/doi/10.1021/jacs.2c10856