Nice papers that #neutrophils can also be epigenetically reprogrammed by infection - stemming from effects on stem cells.

Both use #zebrafish as model

#Shigella: https://www.science.org/doi/full/10.1126/sciadv.adf9706

#Salmonella: https://www.science.org/doi/10.1126/sciadv.adf9904
#trainedimmunity #immunology #epigenetics

Fascinating to see #trainedimmunity used to condition immunomodulatory responses.

I guess it's about inducing the right #epigenetic programme, and then the functional effect can be anything.
#immunology #macrophages @JExpMed #tolerance #immunmodulation #science
https://rupress.org/jem/article/220/11/e20221388/276204/Trained-immunity-of-alveolar-macrophages-enhances?guestAccessKey=6d53512f-5c93-4720-8180-9180f44cda67&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2q1v95-cqesgb-cwe4ixj4

@cellreports Lower female survival from an opportunistic infection reveals progesterone-driven sex bias in #TrainedImmunity
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01018-5?rss=yes&utm_source=dlvr.it&utm_medium=twitter

#IDMastodon #immunology #viralimmunology Differences in #immuneresponses in males and females can sometimes favour one or the other sex. A sex bias in #trainedimmunity where F displayed decreased inflammatory responsiveness & survival from opportunistic infection compared vs M .#COVID19 pandemic reported immune hyper-responsiveness in M with increased morbidity & severity. In contrast,it has been proposed that females may suffer greater morbidity and severity from many other infectious agents.

RT @martinzach_
Watch top immunologists and philosophers discussing hot topics in #TrainedImmunity #cancer #TissueRepair #DiseaseTolerance #RNA and more!

Feat. Mihai Netea @ProfJudiAllen @MiguelCheSoares @pradeu @Dr_inPhieVeigl @BartlomiejSwia4 @FilippLab M. Tencerova
https://www.youtube.com/playlist?list=PL6tK2CutTH9-tcxz3IUrtsT8Xh8WnWMpU