Researchers identify #protein that helps tell #plants 'no' when #nitrogen is low.
#endocrine #signalling #semiochemistry #STOP1 #TCP20 #transcriptome
#protein #plants #nitrogen #endocrine #signalling #semiochemistry #stop1 #tcp20 #transcriptome
Loic Binan of the Broad:
All-optical genetic screens of intracellular and intercellular #transcriptional circuits with Perturb-FISH
Various CRISPR-based methods to look (multiplexed) at outcomes after knockdown to explore gene expression circuits, those are great, but want richer data (morphology etc)
one guide per cell (knock down one gene per cell) see #transcriptome via MERFISH, then identify the perturbed gene via in situ T7 transcription (same chemistry as MERFISH)
1/2
#cssinglecells23 #transcriptome #transcriptional
GAGE-seq for 3D genome and transcriptome co-profiling within the same single cell
https://www.biorxiv.org/content/10.1101/2023.07.20.549578v1
#singlecell #transcriptome #Genomics
#singlecell #transcriptome #genomics
Study reveals how a tall #spruce develops defense against hungry #weevils.
#genomics #stone_cells #transcriptome #Pissodes #Picea #evolution
https://phys.org/news/2023-07-reveals-tall-spruce-defense-hungry.html
#spruce #weevils #genomics #stone_cells #transcriptome #pissodes #picea #evolution
Artificially modulating #stomatal development may improve #crop #stress tolerance.
#transcriptome #regulation #guardcells #VIGS
https://phys.org/news/2023-06-artificially-modulating-stomatal-crop-stress.html
#stomatal #crop #stress #transcriptome #regulation #guardcells #vigs
Researchers discover #Chinmo, 'the youth #gene'
#chinmo #gene #br_c #e93 #maturation #regulation #transcriptome
Predicting Which Bladder Cancer Patients Will Respond to Immunotherapy #urology #bioinformatics #transcriptome
#transcriptome #bioinformatics #urology
Association of 18-Gene expression profile (GEP) with clinical outcomes in patients with metastatic triple-negative breast cancer (mTNBC) treated with pembrolizumab (Pembro) or chemotherapy (Chemo) in KEYNOTE-119 #GeneExpressionProfiling #transcriptome
https://www.esmoopen.com/article/S2059-7029(23)00605-1/fulltext
#transcriptome #geneexpressionprofiling
Timing is everything: New insights into #floral #development unveil nature's perfect clock.
#transcriptome #regulation #meristem #AGAMOUS
https://phys.org/news/2023-05-insights-floral-unveil-nature-clock.html
#floral #development #transcriptome #regulation #meristem #agamous
How a sea #anemone uses its #algal #symbionts to assimilate #nitrogen in nutrient-poor waters.
https://phys.org/news/2023-05-sea-anemone-algal-symbionts-assimilate.html
#anemone #algal #symbionts #nitrogen #RNA #transcriptome
Shamless plug warning! โ ๏ธ
Our last paper on #transcriptional heterogeneity of #pediatric #cancer is out.
Did you think a quiet #genome translates into a quiet #transcriptome? Think again!
#multiscale #clustering on a pan-cancer #RNASeq cohort revealed new diagnostic subtypes and helped us train a #cnn model to identify tumour components in #clinical #oncology samples.
Read it here, it's #openaccess: https://www.nature.com/articles/s41591-023-02221-x
#ml #machinelearning #Transcriptomics #precisionmedicine #openaccess #oncology #clinical #cnn #rnaseq #clustering #multiscale #transcriptome #genome #cancer #pediatric #transcriptional
New #computational method to identify location of #cell types in a sample.
#computational #cell #ai #cytospace #RNA #transcriptome
Team co-maps #proteins and #transcriptome in #human tissues.
https://phys.org/news/2023-03-team-co-maps-proteins-transcriptome-human.html
#proteins #transcriptome #human
Retrospective analysis of #enhancer activity and #transcriptome history
#transcriptomics #epigenomics
https://doi.org/10.1038/s41587-023-01683-1
#enhancer #transcriptome #transcriptomics #epigenomics
๐ข Don't miss: Tuuli Lappalainen @tuuliel_lab (@nygenome @KTHuniversity @scilifelab) will speak at our #DahlemColloquium!
๐ Functional variation in the human #genome: lessons from the #transcriptome
๐ 27. FEB, 11:00 AM (CET)
๐ @MPI_MolGen, #Berlin
๐ https://www.molgen.mpg.de/events/33625/3967495
#dahlemcolloquium #genome #transcriptome #berlin
New article on the #genetic strucutre #Paramuricea #octocorals: with #microsatellites and #transcriptome data we study the Atlantic/Mediterranean divergence, and a cryptic lineage in the Atlantic. More information here: https://onlinelibrary.wiley.com/doi/full/10.1002/ece3.9740
#genetic #paramuricea #octocorals #microsatellites #transcriptome
Avian #flu could decimate Australian black #swans.
#genomics #epizootic #HPAI #transcriptome
https://phys.org/news/2023-01-avian-flu-decimate-australian-black.html
#flu #swans #genomics #epizootic #hpai #transcriptome
New study decodes one of the world's fastest #cell #movements.
#Heliozoan #axopodia #Raphidocystis #tubulin #transcriptome
https://phys.org/news/2023-01-decodes-world-fastest-cell-movements.html
#cell #movements #heliozoan #axopodia #raphidocystis #tubulin #transcriptome
Oh now this is fun
Nielsen etc did absolute-calibrated #proteome #transcriptome and #metabalome on yeast in chemostats (C-limited), so another dope data set for the #PieChart Theory of #MicrobialGrowth
Also estimating the % occupancy of individual #enzyme , that 35 or so are >90% used up for throughput, so maybe limiting metabolic chokepoints
Oh and tldr #amino-acids are super limiting so #aminoacidMetabolismRules
#proteome #transcriptome #metabalome #piechart #microbialgrowth #enzyme #amino #aminoacidmetabolismrules
RT @AbioticStress
Article by @HimabinduKudapa @RutwikBarmukh @GargVanika @Anuchitikineni @rajvarshney @IJMS_MDPI
Comprehensive #Transcriptome Profiling Uncovers Molecular Mechanisms & Potential Candidate #Genes Associated with #HeatStress Response in #Chickpea
#transcriptome #genes #HeatStress #chickpea #plantsci