'Here, our goal is to review distinct domains of Treg function in the host response to respiratory infection and subsequent lung injury and discuss open questions in the field that should be addressed as Treg-based therapeutics move into translation.'
#Immunology #tregs
https://www.jci.org/articles/view/170505

A #YTHDF2/#m6A/NF-κB axis controls #antitumor #immunity by regulating intratumoral #Tregs

Linda Zhang, Chuan He and colleagues

https://www.embopress.org/doi/full/10.15252/embj.2022113126

Also in @sciencemagazine this week: Giuseppe Matarese pens a Perspective on the link between #obesity and #autoimmunity!

https://bit.ly/Sci_ade0113

#immunometabolism #overnutrition #T1D #MS #Tregs #adipocytes #CaloricRestriction #immunotherapy

"We observed increased TGFβ-mediated induction of FoxP3+ cells in the presence of extracellular lactic acid, in a glycolysis-independent, acidity-dependent manner."

#immunology #Metabolism #Tregs

https://www.nature.com/articles/s41579-022-00837-3?utm_source=nrmicro_etoc&utm_medium=email&utm_campaign=toc_41579_21_3&utm_content=20230216

And your annual reminder that some of the most profound and transformative insights into #immunology (such as the discovery of #Tregs!) were made studying chicken immunology

RT @Pirbright_Inst@twitter.com

JOB: Our Avian Immunology research group are looking for a Postdoctoral Scientist to investigate the immunogenicity and efficacy of novel vaccines in chickens.

Apply now ➡️http://ow.ly/cHjV50Mi7U4

🐦🔗: https://twitter.com/Pirbright_Inst/status/1610666163343605763

Solomon and Kazushige show a novel mechanism of T regulatory cell-mediated suppression of CD4 activation through the inhibition of mRNAs encoding protein synthesis machinery. Here we show T regulatory cells shape effector T cell translatome. This is a result of a fantastic collaboration with Steve Ziegler's lab. We thank all the co-authors who contributed to this work. #RNA #Tregs #Tolerance #Autoimmunity

https://rupress.org/jem/article/220/3/e20221676/213791/Regulatory-T-cells-suppress-CD4-effector-T-cell

RT @DrFAlzaid@twitter.com

Latest curated articles👇🏽
📰PD1 deletion destabilizes lineage identity & metabolic fitness of tumor-infiltrating #TRegs (📷)
📰#SREBP is essential for #Bcell responses
🧠Mouse brain aging single cell molecular & spatial signatures
🔗http://biomed.news/bims-nimamd/2023-01-01
🙏🏽Thx @Bims_BiomedNews@twitter.com

🐦🔗: https://twitter.com/DrFAlzaid/status/1609649287515803649

Latest curated articles👇🏽
📰PD1 deletion destabilizes lineage identity & metabolic fitness of tumor-infiltrating #TRegs (📷)
📰#SREBP is essential for #Bcell responses
🧠Mouse brain aging single cell molecular & spatial signatures
🔗http://biomed.news/bims-nimamd/2023-01-01
🙏🏽Thx @Bims_BiomedNews@twitter.com

Back at my old undergraduate campus to give a seminar on #Tregs and #neuroimmunology @UniofAdelaide@twitter.com

First steps here and learning! Time for #introduction part2 with hashtags. I’m a physician-scientist in Helsinki 🇫🇮 (the happiest people on Earth live here!) and topics close to my heart are (not in any order) #thymus #myastheniagravis #aps1 #AIRE #helios #Tfh #tregs #MAITs #RTEs #thymopoiesis #immunodeficiency #immunology #immunophenotyping #flowcytometry #humanimmunology #viruses #viralimmunology #GerminalCenters #SingleCell #Transcriptomics - here to read and learn more about these!

"Madi et al. report the surprising finding that human and murine FOXP3+ Tregs are a physiological relevant source of Interleukin-15, a homeostatic cytokine that promotes antigen-independent maintenance of CD8+ memory T-cells. In mice that lack IL-15 selectively in FOXP3+Tregs the authors show that the composition of the CD8+ T-cell memory pool is altered in the absence of Treg-derived IL-15, since a subset of terminally effector memory cells is drastically reduced."

#Immunology #Tregs #Cytokines

https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250238

In #Science (@sciencemagazine) this week, the Hanahan lab shows that the #RNA-binding protein #FMRP enables #tumors to evade being attacked by #CD8TCells. It does so by both suppressing #CCL17 & promoting #Tregs via #IL33 & #M2 #macrophages via #PROS1 & #ExtracellularVesicles!

https://bit.ly/Sci_abl7207

#CancerImmunology #RBP