CellBioNews · @cellbionews
38 followers · 913 posts · Server scientificnetwork.deResearchers reveal structural basis of #plp2-mediated #cytoskeletal #protein #folding by #TRiC/CCT
https://phys.org/news/2023-03-reveal-basis-plp2-mediated-cytoskeletal-protein.html
#plp2 #cytoskeletal #protein #folding #tric
The EMBO Journal · @embojournal
403 followers · 85 posts · Server sciencemastodon.com
Protein complex assembly #qualitycontrol in action:
#cryoEM structures by Nico Thomä at FMI and colleagues show how #CRL4-#DCAF12 #ubiquitin E3 #ligase engages a C-terminal di-Glu #degron in CCT5 recognizable only when this subunit is not incorporated into the #TRiC/#CCT #chaperone complex
https://www.embopress.org/doi/10.15252/embj.2022112253
#qualitycontrol #cryoem #crl4 #dcaf12 #Ubiquitin #ligase #degron #tric #chaperone