#channelopathies #ionchannels #TRPM4
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RT @biorxivpreprint
Amino acid substitution in the S1 or CH1-CH2 linker domain of TRPM4: Two new TRPM4 variants found in complete heart block patients lead to gain of expression and gain of current https://biorxiv.org/cgi/content/short/2023.03.29.534743v1 #bioRxiv
https://twitter.com/biorxivpreprint/status/1641264045930995714

@biorxivpreprint

^ "Further, we reveal key roles for heat-sensitive channels #TRPV1 and #TRPM4 in heat-induced myogenic tone in the skeletal muscle, both in vitro and in vivo. Elevations in temperature are known to increase tissue perfusion by altering blood viscosity; remarkably, we demonstrate that thermosensitive tone counterbalances this effect. Thus, the thermosensitivity of myogenic tone is tuned to tissue temperature and serves as a fundamental mechanism to regulate local blood flow."

RT @ajpheartcirc
#ArticlesInPress: Multiomics uncover the pro-inflammatory role of #Trpm4 deletion after #myocardial infarction in mice
(Boukenna et al.)
http://ow.ly/yjHi50MXrn5
#myocardialInfarction #CardiacInflammation
@SwissIonChannel

Boukenna (1st 1st authorship) et al. paper is now online - "Multiomics uncover the pro-inflammatory role of #Trpm4 deletion after myocardial infarction in mice" -> Loss of the #TRPchanel TRPM4 increases cardiac fibrosis post #MyocardialInfarction.

https://journals.physiology.org/doi/abs/10.1152/ajpheart.00671.2022#

A new scientist is born! Varjany Vashanthakumar (biomedical master's student @uniofbern @unil) gave a fantastic short talk (her first!) at the @LS2Switzerland @LS2_ICMT symposium on #IonChannels #TRPM4 #Channelopathies. Best of luck with your next goal, dear Varjany!