@biorxivpreprint

^ "Further, we reveal key roles for heat-sensitive channels #TRPV1 and #TRPM4 in heat-induced myogenic tone in the skeletal muscle, both in vitro and in vivo. Elevations in temperature are known to increase tissue perfusion by altering blood viscosity; remarkably, we demonstrate that thermosensitive tone counterbalances this effect. Thus, the thermosensitivity of myogenic tone is tuned to tissue temperature and serves as a fundamental mechanism to regulate local blood flow."

research article (2019):
Puerarin suppresses TRPV1, calcitonin gene-related peptide and substance P to prevent paclitaxel-induced peripheral neuropathic pain in rats
https://doi.org/10.1177/0333102417748563
~
Puerarin is a natural product found in kudzu root. Kudzu root is used to make Japanese kuzu noodles - don't know how much puerarin is in kuzu starch, but it's used traditionally as a digestive aid.

#2badItsPaywalled #CGRP #TRPV1 #NaturalProducts #FunctionalFoods
#puerarin #kuzu #neuropathy #ChronicPain

"Transient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin and noxious heat, has been one of the most compelling targets for analgesics. However, systemic inhibition of TRPV1 is an impractical approach as a pain killer, since systemic antagonism induces hyperthermia. Two articles in this issue of the JCI report phenotypes from separate, rare missense mutations of human TRPV1."

#neuroscience #SensoryNeuroscience #trpv1

https://www.jci.org/articles/view/167338

RT @ionchannellib
Why does wasabi burn the nose?

See here:
https://www.linkedin.com/feed/update/urn:li:activity:7028510548094808064

#ionchannels #wasabi #trpa1 #trpv1