New preprint from Sam Dean and colleagues introducing molecular tools for tagging in Tryps:

Unlocking Trypanosome Biology: A Comprehensive Protein-Tagging Toolkit for Localization and Functional Analysis

https://www.biorxiv.org/content/10.1101/2023.04.21.537815v1

#CellBiology #MolecularBiology #Trypanosomes

amazing stuff - Olympic rings in the kinetoplasts of #Trypanosomes!
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RT @Dmichiel1
🚨Our "Single-Molecule Structure and Topology of Kinetoplast DNA Networks" is now live @PhysRevX!!
Very fun and productive collaboration with @LucaTubiana and @cees_dekker lab.
https://journals.aps.org/prx/abstract/10.1103/PhysRevX.13.021010
A short tweetorial for the interested (1/n)
https://twitter.com/Dmichiel1/status/1648711925507715074

African #trypanosomes #mapped for the first time to understand #evolution and potential treatments.

#proteomics #genomics

https://phys.org/news/2023-03-african-trypanosomes-evolution-potential-treatments.html

I'm research scientist, at #Unifesp and I'm interested in #molecularbiology of #parasites. I apply #proteomics and #genomics to study #Trypanosomes. Our research also focus on #DrugDiscovery and #targetidentifcation. I'm editor in chief of #CellBiologyInternational. At the personal level I'm a #swimmer / #bycicles / and #trails.

Hello. I am a professor at #Clemson. My lab studies #parasitic #protozoa including African #trypanosomes and pathogenic #free-living #amoebae.

#Parasitology paperwatch: recent work from
De Graffenried lab (FA: RS Muniz, PC Campbell) adapting a live-cell #imaging technique from bacteria to #trypanosomes, namely confinement of single cells to agarose microcells.

They show how the ability to track single cells over the entire cell cycle can lead to new insights. Show specifically that the 2 daughter cells produced after cell division go on to divide at different time (the one with the old flagellum is faster)

Also address recent controversy regarding a putative "backup cytokinesis" pathway triggered in TOEFAZ1/CIF1 RNAi, & show that the proposed pathway is not operating 🤩. Good description of how setup & imaging conditions were optimised & excellent suggestions for future applications of the approach😃👏👍

https://dx.plos.org/10.1371/journal.ppat.1010218

An #Introduction from us - we are the Department of #CellBiology & Developmental Biology at the University of #Würzburg in 🇩🇪. We love #trypanosomes! (and #trypanosomatids).

Toots will generally cover the following topics:
- News from the department (papers, PhDs, new arrivals).
- Papers of interest in #MolecularParasitology.
- Random observations about life in 🇩🇪 .

Great to be here and we're looking forward to connecting with the community! :ablobsmile: