How do we solve a problem like tuberculosis?

#tuberculosis #TB #microbiology #immunology #publichealth #AMR #pupulatioscience #laboratoryscience #vaccines

https://www.nature.com/articles/s41564-023-01477-w?utm_source=nmicrobiol_etoc&utm_medium=email&utm_campaign=toc_41564_8_9&utm_content=20230831

"While #JohnsonAndJohnson’s main patent for #bedaquiline expired in July, it had faced criticism for using secondary patents – in which small modifications are made to a product to extend a #patent and prevent a product from being sold by competitors." #GenericDrugs

Cost of #tuberculosis treatment halved in deal to permit generic versions | Global development | The Guardian
https://www.theguardian.com/global-development/2023/aug/31/cost-of-tuberculosis-treatment-halved-in-deal-to-permit-generic-versions

Sharing a paper I'm co-first-author on out today in BMC Medicine:

Tabby2: a user-friendly web tool for forecasting state-level TB outcomes in the United States

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02785-y

This is our writeup about the #shiny app we built to allow users to flexibly forecast the effects of interventions on tuberculosis, including improvements to targeted testing and treatment, diagnostics, and improvements to the care cascade.

#EpiVerse #Epidemiology #TB #Tuberculosis #Web #rstats @rstats

New research in India demonstrates the effectiveness of providing food aid to households with tuberculosis patients in preventing and mitigating the disease.

https://theconversation.com/tb-research-shows-a-good-diet-can-cut-infections-by-nearly-50-211377

#tuberculosis
#health

#tuberculosis #tb #immunology has anyone good publications or personal experience in HTD with IL1 antagonist in tb. Preferably extra cranial? Wondering about the safety in say pulmonal or lymph manifestations….

@HeavenlyPossum Said shortness was far more likely due to disease than any form of intent-based violence.

Westerners got really used fast to not dying of #cholera, #tuberculosis or even just #influenza (those fevers without medication aren't just unpleasant). To the point they forgot that these diseases were killing in significant numbers all the way up to the middle of the 20th century (they never actually stopped, direct killing or indirect via long-term damage).

@dalias @petersuber Honestly, just remembering previous #tuberculosis #epidemics (https://en.wikipedia.org/wiki/Open_air_school), #BlackMold and such, it should have been obvious that the moment #AirPurification / #AirSanitation became possible, it should've been mandatory.

For sure masks as well, but we might well just... not have air-transmitted epidemics & pandemics anymore if #AirQuality was a basic thing one could assume to be good everywhere.

M. #tuberculosis (Mtb) resists killing by repressing the #autophagolysosome machinery. @imgsb show that NCoR1 regulates these processes in myeloid cells by fine-tuning ATP homeostasis via AMPK-mTOR-TFEB axis, so controlling Mtb #pathogenesis #PLOSBiology https://plos.io/3quNEGD

If you need one video to convince you why why the cures for tuberculosis should be cheap and available everywhere? This is the one.

Thank you, John Green.

https://www.youtube.com/watch?v=JhVJMO0wgTE

#tuberculosis

@Die_Primel isn't it a #British #Tradition to trow #Marginalized people under the bus?

And creating an #epidemic of #tuberculosis among migrants and basically murdering them on a boat by criminal neglect and denial of medical care and isolation isn't so much out of this world as it seems for anyone who knew how the "#UK" treated #Ireland buring the late 1840s.

https://www.youtube.com/watch?v=E4Dc0ltgf3I&list=PLYy6-QUJ2ZyjWXpOdgxvIY_K5fSLkyX8C&index=2

Today in Squirrel News: #solarpower is becoming essential as Europe grapples with severe #heatwaves, African teams are showing fantastic success at the Women's #WorldCup, a new AI-supported method is helping to diagnose #tuberculosis & much more👇.
https://squirrel-news.net/news/solar-saves-europe-in-heatwave-african-teams-succeed-at-womens-world-cup-ai-takes-on-deadliest-disease/

Why should we do RCTs, exhibit 185

The 3 month TB protocol RCT stopped early as it is worse than standard therapy

NIH press release https://www.nih.gov/news-events/news-releases/investigational-three-month-tb-regimen-safe-ineffective-nih-study-finds

#IDMastodon #tuberculosis

Diagnostics to support the scaling up of shorter, safer tuberculosis regimens - The Lancet Microbe

#TB #tuberculosis #infectiousdiseases #policy #IDMastodon #publichealth #diagnostics #medicine #antibiotics #AMR

https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00217-3/fulltext?dgcid=raven_jbs_aip_email

Second deadly TB outbreak linked to tainted bone grafts https://wapo.st/45ehm13

#giftarticle #Usa
#news #healthcare

U.S. health officials are racing to control an outbreak of #tuberculosis linked to contaminated bone graft material that has killed one person and infected at least four others — the second outbreak of the rare disease in two years.
Eight people died in 2021 when

Food for thought - #TB #tuberculosis remains a BIG problem!
#infectiousdiseases #IDMastodon #medicine #MedMastodon

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00361-0/fulltext?dgcid=raven_jbs_aip_email

@HenningT6

Sehr gut, Danke

Das Thema adequater Schutzausrüstung gegen airborne, luftübertragener ,infektiöser Partikel
insbesondere in medizinischen Einrichtungen
bedarf mehr öffentliche Aufmerksamkeit

#covid
#SarsCoV2
#ebola
#tuberculosis
#monkeypox
#RSV
#measles
#CovidIsNotOver
#COVIDisAirborne

Gizmodo: So, What's Going On With Leprosy in Florida? https://gizmodo.com/so-whats-going-on-with-leprosy-in-florida-1850696205 #healthmedicalpharma #mycobacteriumleprae #pathogenicbacteria #infectiousdiseases #bacterialdiseases #tropicaldiseases #leprosystigma #tuberculosis #infection #zoonosis #leprosy #disease #hansen #lepra

Johnson & Johnson Letting Nonprofit Distribute Life-Saving Generic Tuberculosis Drug—Greatly Expanding Access In Poorer Countries

https://www.forbes.com/sites/willskipworth/2023/07/13/johnson--johnson-letting-nonprofit-distribute-life-saving-generic-tuberculosis-drug-greatly-expanding-access-in-poorer-countries/?sh=68607ceb3dcd

#Tuberculosis

egads. company selling bone grafts for surgeries has to recall a second batch for contamination with #tuberculosis. The first batch infected 87 people.

https://arstechnica.com/health/2023/07/not-again-bone-grafts-linked-to-another-deadly-bizarre-tb-outbreak/

The government has no record of how many of these #MigrantChildren are actively receiving treatment for #tuberculosis

https://www.naturalnews.com/2023-07-23-govt-released-illegal-immigrant-kids-latent-tuberculosis.html