Two+ weeks 🚨 19/09/2023 15:00-17:15 BST 🚨until our 45th BSCB GenSoc UK Cilia Network e-symposium- free and open to all! >1260 folks already registered, this is the #cilia #centriole place to be! Not on my list already, sign up here: https://www.eventbrite.co.uk/e/bscb-gensoc-uk-cilia-network-e-symposia-series-tickets-122092125835
We have all good things lined-up: #GeneRegulatoryNetworks, #Signalling, mind-blowing #cryoET protein ID, #OrganelleProteomics in #neurons AND everything #tubulin! Join us...
#tubulin #neurons #organelleproteomics #cryoet #signalling #generegulatorynetworks #centriole #cilia
Autism-associated genes exert pleiotropic effects.
“Over 200 genes are associated with autism spectrum disorder (ASD).”
“…data are consistent with a role for tubulin biology in ASD pathogenesis and suggest that ASD-associated chromatin regulators can have pleiotropic effects”
#Genetics #Science #Autism #Tubulin #Medicine #MedMastodon
#MedMastodon #medicine #tubulin #autism #science #genetics
How does #centrosome #amplification -common in #cancer- promote #cellmigration through confined spaces?
Susana Godinho and colleagues show that it alters intracellular organization via effects on #tubulin #acetylation and #organelle transport along #microtubules
https://www.embopress.org/doi/full/10.15252/embj.2022112812
#centrosome #amplification #cancer #cellmigration #tubulin #acetylation #organelle #microtubules
As Stuart Hameroff and Sir Roger Penrose suggest, Tryptophan residues in #microtubules influence #consciousness. In this 3D print of Microtubule 3J2U, we can see how TRP residues (tinted dark) interconnect adjacent #Tubulin molecules. #structuralbiology
https://biologicmodels.com/pdb/3j2u/microtubule-3j2u/?aiEnableCheckShortcode=true
#microtubules #consciousness #tubulin #structuralbiology
As Stuart Hameroff and Sir Roger Penrose suggest, Tryptophan residues in #microtubules influence #consciousness. In this 3D print of Microtubule 3J2U, we can see how TRP residues (tinted dark) interconnect adjacent #Tubulin molecules. #structuralbiology
https://biologicmodels.com/pdb/3j2u/microtubule-3j2u/?aiEnableCheckShortcode=true
#microtubules #consciousness #tubulin #structuralbiology
As Stuart Hameroff and Sir Roger Penrose suggest, Tryptophan residues in #microtubules influence #consciousness. In this 3D print of Microtubule 3J2U, we can see how TRP residues (tinted dark) interconnect adjacent #Tubulin molecules. #structuralbiology
https://biologicmodels.com/pdb/3j2u/microtubule-3j2u/?aiEnableCheckShortcode=true
#microtubules #consciousness #tubulin #structuralbiology
New study decodes one of the world's fastest #cell #movements.
#Heliozoan #axopodia #Raphidocystis #tubulin #transcriptome
https://phys.org/news/2023-01-decodes-world-fastest-cell-movements.html
#cell #movements #heliozoan #axopodia #raphidocystis #tubulin #transcriptome
#Invitro #reconstitution assays with purified brain #tubulin from mouse models lacking specific tubulin-modifying #enzymes show that tubulin #polyglutamylation patterns differentially regulate #microtubule-interacting protein binding
Carsten Janke, Marcus Braun and coworkers
https://www.embopress.org/doi/10.15252/embj.2022112101
#invitro #reconstitution #tubulin #enzymes #polyglutamylation #microtubule
Researchers discover how a nano-chamber in the #cell directs #protein #folding.
https://phys.org/news/2022-12-nano-chamber-cell-protein.html
#cell #protein #folding #tubulin #chaperonins
Lovely #preprint from Minhajuddin Sirajuddin's team led by @mamata with awesome 😍 TIRF microscopy, in vitro reconstitution & #cryoEM, to illustrate how FAP20 recruits #tubulin to #microtubule lattice driving assembly of #cilia #MTDs, by joining the A- and B-tubules. https://www.biorxiv.org/content/10.1101/2022.11.25.517946v1
#mtds #cilia #microtubule #tubulin #cryoem #preprint
Lovely #preprint from Minhajuddin Sirajuddin's team led by @mamata with awesome 😍 TIRF microscopy, in vitro reconstitution & #cryoEM, to illustrate how FAP20 recruits #tubulin to #microtubule lattice driving assembly of #cilia #MTDs, by joining the A- and B-tubules. https://www.biorxiv.org/content/10.1101/2022.11.25.517946v1
#mtds #cilia #microtubule #tubulin #cryoem #preprint