Is loss of #RAD51 #recombinase function pro-tumorigenic similar to other homologous recombination factor mutations?
New mouse model reveals a premature aging, but anti-#tumorigenic effect of dominant-negative SMRAD51 expression!
Gabriel Matos-Rodrigues, Bernard Lopez, Emmanuelle Martini and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022110844

Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510