The EMBO Journal · @embojournal
534 followers · 266 posts · Server sciencemastodon.com
What can bacteria teach us about unexplored areas of #ubiquitin signaling and regulation?
John Pruneda and colleagues discuss how #pathogens subvert the host cell #ubiquitination system by either adopting or breaking its rules
New review article as #weekendreading!
#Ubiquitin #pathogens #ubiquitination #weekendreading
The EMBO Journal · @embojournal
532 followers · 265 posts · Server sciencemastodon.com
#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481
#march5 #nlrp3 #ubiquitination #mitochondrial #inflammasome
PLOS Biology · @PLOSBiology
5255 followers · 1671 posts · Server fediscience.org
Mutations in PARK15/FBXO7 cause #ParkinsonsDisease. @alsanchezmar @Aitor_Mtz & @whitworth_lab shows that its fly ortholog works antagonistically with USP30 to set the #ubiquitination threshold needed to regulate basal #mitophagy #PLOSBiology https://plos.io/3qfaUZ1
#plosbiology #mitophagy #ubiquitination #parkinsonsdisease
The EMBO Journal · @embojournal
426 followers · 140 posts · Server sciencemastodon.com
A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage
#protelysis #Recombination #knoten1 #ubp12 #ubiquitination #autophagic #BLM #rmi1 #dnadamage
The EMBO Journal · @embojournal
415 followers · 109 posts · Server sciencemastodon.com
Surprising interplay between #SMC5/6 and #transcription-regulating #PAF1 complexes in #Arabidopsis #DNAdamage response:
Shunping Yan and colleagues find them to interact and recruit E2/E3 enzymes for #histone H2B #ubiquitination at DNA double-strand breaks
https://www.embopress.org/doi/10.15252/embj.2022112756
#smc5 #transcription #paf1 #arabidopsis #dnadamage #histone #ubiquitination
Kurianlab · @kurianlab
43 followers · 98 posts · Server sciencemastodon.com
RT @iDikic2
Students and postdocs interested in #ER remodeling and #autophagy and #ubiquitination and their impact on development of human diseases please consider this @ERC_Research grant 😀😉🙃
@IBC2_GU @goetheuni @sfb1177 @RMU_EMTHERA
#er #autophagy #ubiquitination
Hao Yin · @HaoYin
163 followers · 107 posts · Server qoto.org
K63 #Ubiquitination of #YAP by SKP2 #E3Ligase⏫its nuclear import🤠
Synergized with mTORC1-PERK-ATF4 axis in renal #Cystogenesis🐭#JuvenileCysticKidney #Ciliopathy
A #CellCycle-specific regulation of YAP?😆
Dr. Andrew Karaplis lab JCI 2022
https://www.jci.org/articles/view/153943
#yap #ciliopathy #E3Ligase #ubiquitination #Cystogenesis #JuvenileCysticKidney #cellcycle