TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://plos.io/3LB8ITH
#plosbiology #tdp43 #FTD #frontotemporaldementia #Als #amyotrophiclateralsclerosis #unc13a
TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://plos.io/3LB8ITH
#plosbiology #tdp43 #FTD #frontotemporaldementia #Als #amyotrophiclateralsclerosis #unc13a
TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://plos.io/3LB8ITH
#plosbiology #tdp43 #FTD #frontotemporaldementia #Als #amyotrophiclateralsclerosis #unc13a