The #Unknome database of proteins [ranked according to how much we have learned about them] revealed that we still know next to nothing about thousands of human proteins.
ℹ️ Some are essential for survival.
Sean Munro et al @CellBiol_MRCLMB
@newscientist
https://www.newscientist.com/article/2386301-we-know-almost-nothing-about-thousands-of-proteins-in-the-human-body/

The word '#genome' was born in the 1920s when someone blended 'gene' with 'chromosome'. (The -some in 'chromosome' is from a root that means 'body' as in 'somatic' or 'psychosomatic'.)

Then science started adding -omes. Proteome, transcriptome, phenome, even spliceome. But the best by far is the #unknome: the set of all genes of unknown function.

New paper in @PLOSBiology about the unknome does a screen for basic function of these "mystery proteins"

#omics
#proteins
#PLOSBiology

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The '#unknome': A database of human #genes we know almost nothing about.

www.unknome.org

https://phys.org/news/2023-08-unknome-database-human-genes.html

Into the #Unknome. The function of many human genes still remains mysterious; @mjafreeman, Sean Munro &co present an “Unknome database,” and show that screens focusing on the "Unknome" can shed light on fundamental biological processes #PLOSBiology https://plos.io/3YqumhS