Keisuke Shigeta et al (Keio University School of Medicine) analyze #metabolic alterations leading to #chemoresistance in #urothelial cancer #bladdercancer: #IDH2 gain-of-function independent of #mutation is responsible for #HIF1α-dependent production of respective #gemcitabine and #CDDP competitors #dCTP and #NADPH
#metabolic #chemoresistance #urothelial #bladdercancer #idh2 #Mutation #hif1α #gemcitabine #cddp #dctp #nadph
Investigating PSMA differential expression in canine uroepithelial carcinomas to aid disease-based stratification and guide therapeutic selection. https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-022-03544-6 #urothelial #carcinoma #prostate
#urothelial #carcinoma #prostate
Identification of a naturally-occurring canine model for early detection and intervention research in high grade #urothelial #carcinoma. https://www.frontiersin.org/articles/10.3389/fonc.2022.1011969/full