What controls basal, #Parkin-independent #mitophagy?
E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively
#parkin #mitophagy #Ubiquitin #ligase #vhl #fbxl4 #nix #bnip3