“lingering symptoms” is not how I've heard a single person with #LongCovid describe it..

#Disability #ViralPersistence #OrganDamage #Autoimmunity #ShortenedLifeExpectancy

@Juicyfranck @sudnadja
https://www.ncbi.nlm.nih.gov/books/NBK8538/

ignorance is not bliss & they should be more afraid, mainly of the long term consequences
#viralPersistence #PASC
#EndothelialDamage #acceleratedAging

Perhaps it’s b/c I was a kid w/mad active imagination during #Reagan but there was nothing scarier to me than #HIV #AIDS

#SARS2 has replaced that fear b/c there are therapeutics for one & not the other

Given the choice, I’d take #HIV vs repeated♾️reinfection #Covid

#IDMastodon Evidence showing that some #LongCovid patients may not fully clear the #SarsCoV2 #virus after acute infection. Instead, replicating virus and/or viral RNA - potentially capable of being translated to produce viral proteins - persist in tissue as a "reservoir" . This is the best review of #viralpersistence as the driver of #longCOVID to have appeared so far 🧵 by @microbeminded2
https://x.com/microbeminded2/status/1698719941472498013?s=61

#IDMastodon Presence of #SARSCoV2 in middle ear fluid & characterisation of #otitismedia with effusion in #COVID19 patients (Omicron study). Middle ear infections due to #viralpersistence as a possible symptoms in #COVID19 & #LongCovid . This #casereport of the presence of #SARSCoV2 in the middle ears of #COVID19 patients with OME , implying that #SARSCoV2 infection may be a cause of OME( 18/27= 66% )
https://www.sciencedirect.com/science/article/pii/S1201971223007099

#IDMastodon #PedsID @thelancetinfdis Several studies confirm #ViralPersistence in stillborn, in neonates, & in children But #LongCovid is not exceptional, or unique
Viral persistence in children infected with #SarsCoV2 current evidence and future research strategies
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00115-5/fulltext

#Viralpersistence in children infected with #SarsCoV2 current evidence and future research strategies @thelancetinfdis
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00115-5/fulltext

#Viralimmunology #LongCovidKid understanding the Immune responses to #SARSCoV2 infection & vaccination in children
#PostCovid in adults associated with #viralpersistence in 🩸& MIS-C in children is associated with viral persistence in the intestine which is suggesting that tissue specific differences or age-associated differences in immune responses to persistent #SARSCoV2 🦠 may explain these different presentations.
https://www.sciencedirect.com/science/article/pii/S1044532323000854#fig0010

In case you missed it:

A brief, readable review of the evidence for viral persistence in Long Covid, from the Lancet:

"Association of SARS-CoV-2 infection and persistence with long COVID"
https://doi.org/10.1016/S2213-2600(23)00142-X

#virus #virology @virology #ViralPersistence #LongCovid

@GMIK69

1/4
"Atypical Ebola virus disease in a rhesus macaque" (2023)
https://doi.org/10.1093/infdis/jiad283

I really can't understand why they would call this "atypical" disease. 🤔

For all we know, persistence of ebola #virus in immune-privileged tissues months or years after infection may in fact turn out to be quite typical of #ebola infections. [1-5] (references to follow)

(Image from @Angie_rasmussen )
#ViralPersistence #virology

New BMJ Feature:

"Where do viruses hide in the human body?"
https://doi.org/10.1136/bmj.p1156

#RNA #virus #virology @virology #ViralPersistence

🦠 🦟
Saint Louis Encephalitis Virus (SLEV) is a common mosquito-transmitted #virus in the Americas that can cause life-long neurological disability.

Mostly unknown to doctors in the US, there are recent reports from California & Argentina:
https://mstdn.science/@hmpxvt@mastodon.social/110677596096783744
https://outbreaknewstoday.com/argentina-reports-7-saint-louis-encephalitis-cases-in-buenos-aires-and-entre-rios-76639/
(h/t @hmpxvt)

🤔 An open question is whether the life-long neurological disability is due to #ViralPersistence in the brain, as sometimes seen with other flaviviruses:
https://mstdn.science/@pyrrhus/110043486128121333

#virology @virology

#IDMastodon @eLife #clinicalreview #Viralimmunology #Cellimmunity In this #ClinicalReview , multiple researchers with wide-ranging expertise in adult and #pediatricmedicine came together to review the role of the innate and adaptive immune systems in the pathogenesis of acute #SARSCoV2 infection and PASC / #LongCovid .The focus on immune mechanisms here emphasizes the dysregulation of immune processes that are intertwined with the #viralpersistence and tissue-specific pathologies

@kroltanz imo, the simplest explanation as to why monocytes continue to be switched on is that they continue to encounter pathogens 😬

#ViralPersistence #ViralReservoir

https://www.npr.org/sections/health-shots/2023/05/02/1172806898/why-viral-reservoirs-are-a-prime-suspect-for-long-covid-sleuths “Other scientists trying to uncover the roots of #LongCOVID have asked some version of that same question for the last few years now. This theory of "#ViralPersistence" posits that some people never fully eliminate the infection, that #ViralReservoirs are subsisting in the body and possibly triggering the symptoms of long COVID.”

P.S.

And for comparison, here's a completely different model of how an RNA #virus can establish a quasi-latent state to facilitate #ViralPersistence:

"Some #RNA viruses, such as mumps, can establish persistent infections by freezing its intracellular viral replication factories as condensates."
https://mstdn.science/@pyrrhus/110275180043677194

New publication of so-called #TeamClots with #ResiaPretorius on the pathophysiology of #LongCovid. The focus is on #Microclots.
But also other theories like #Autoimmunity and #ViralPersistence are mentioned.

#PostCovid #MECFS #Covid #Corona #Covid19 #Science

https://www.sciencedirect.com/science/article/pii/S1043276023000553

2/2
The authors also found hints of viral "latency" associated with longer infection times.

This would suggest that the rate of viral replication might slow down as the infection proceeds, possibly resulting in a quasi-latent state characterized by very low replication and protein synthesis.

How could this be? How could an #RNA virus slow its rate of viral replication and protein synthesis to help it to persist?

Well, here's just one possible way:
https://mstdn.science/@pyrrhus/109507942028202866
#ViralPersistence

https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6035
came to this conclusion July 2022 when 2 ancient ninnies nearly gave me a #sarscov2 infection after briefly opening my door for 30 secs & stupidly un-masking after closing🚪

1 of them visibly sick again circa Nov but was imho #asymptomatic spreading everywhere she went & still is

So yes,constant infection DOES hide severe symptoms but #viralPersistence & constant exposure…is a recipe for a slow yet simultaneously quick☠️🪦

#youDoYouBoo 🤷🏻‍♀️🙄#whatever
@jmcrookston

2/3
In addition to the above ☝️, there is another persistent brain infection that has been compared to persistent measles infection:

Dengue virus — which infects hundreds of millions of people, each and every year.

"Chronic Dengue Virus Panencephalitis in a Patient with Progressive Dementia with Extrapyramidal Features"
https://doi.org/10.1002/ana.25588
#virus #virology @virology #ViralPersistence

1/3
If you found the above☝️study eye-opening, consider that Deer Tick/Powassan Virus(POWV) may persist in the brain, as studied in this new paper:

"Of Murines & Humans: Modeling Persistent Powassan Disease in C57BL/6 Mice"
https://doi.org/10.1128/mbio.03606-22

Specifically, the authors found that the #virus may persist in the brain without creating infectious particles, perhaps just as measles can persist in the brain without creating infectious particles:
https://pubmed.ncbi.nlm.nih.gov/6879001/
#virology #ViralPersistence