Furqan Shah · @furqanshah
51 followers · 78 posts · Server mstdn.science
#Magnesium #whitlockite formation in the alveolar #bone, with #bisphosphonate exposure and osteolytic #skeletal #metastasis. Scanning electron microscopy, Micro-Raman spectroscopy, and energy dispersive X-ray spectroscopy reveal Mg-rich, rhomboidal nodules (200 nm to 2.4 µm) within the lacuno-canalicular space. Mg-whitlockite formation in #osteocyte lacunae is multifactorial in #nature and suggests altered bone #biomineralization.
#magnesium #whitlockite #bone #bisphosphonate #skeletal #metastasis #osteocyte #nature #biomineralization #biology #pathology #Science
Furqan Shah · @furqanshah
45 followers · 73 posts · Server mstdn.science#Magnesium #whitlockite formation in the alveolar #bone, with #bisphosphonate exposure and #osteolytic #skeletal #metastasis. Scanning electron microscopy, Micro-Raman spectroscopy, and energy dispersive X-ray spectroscopy revealed Mg-rich, rhomboidal nodules (~200 nm to ~2.4 µm) within the lacuno-canalicular space. Mg-whitlockite formation within #osteocyte lacunae is multifactorial in #nature and suggests altered bone #biomineralization.
#magnesium #whitlockite #bone #bisphosphonate #osteolytic #skeletal #metastasis #osteocyte #nature #biomineralization #biology #pathology
Furqan Shah · @furqanshah
45 followers · 73 posts · Server mstdn.science
Here's a transmission electron microscopy (TEM) image of #bone showing mineralized #collagen and an #osteocyte lacuna containing microcalcifications of #apatite and #whitlockite.
Such #calcification or #mineral formation is part of normal physiological processes such as #apoptosis but can also indicate #pathology.
The specimen was prepared using focussed ion beam scanning electron microscopy (FIB-SEM).
Read more:
https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.7b02888
#bone #collagen #osteocyte #apatite #whitlockite #calcification #mineral #apoptosis #pathology #ThinSectionThursday #biomaterials #ElectronMicroscopy