RT @science_charles
One #drug in many ways. The #absorption, #distribution, #metabolism, and #excretion of #xenobiotics are affected by many #genes. A new study focuses on phenotypic and genomic analysis of those in several #populations. Read more in @GenomeBiolEvol

🔗https://pubmed.ncbi.nlm.nih.gov/36445690/

(MK)

Part of the complexity lies in the relationship between genotype, phenotype and environment. This is exemplified by 3 papers on #resistance to #xenobiotics:
Einspanier et al https://doi.org/10.1111/eva.13350
Cohen et al https://doi.org/10.1111/eva.13498
Roy et al https://doi.org/10.1111/eva.13417

Wikipedia defines #Pharmacometrics (#PMx) as a field of study of the methodology and application of #models for disease and pharmacological measurement. It applies mathematical models of #biology, #pharmacology, #disease, and #physiology to describe and quantify interactions between #xenobiotics (drugs) and patients (human and non-human), including both beneficial and adverse effects.